Positively Correlated CD47 Activation and Autophagy in Umbilical Cord Blood-Derived Mesenchymal Stem Cells during Senescence

Autor: Gee-Hye Kim, Yun Kyung Bae, Ji Hye Kwon, Miyeon Kim, Soo Jin Choi, Wonil Oh, Soyoun Um, Hye Jin Jin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Stem Cells International, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 1687-966X
1687-9678
25839012
DOI: 10.1155/2021/5582792
Popis: Autophagy plays a critical role in stem cell maintenance and is related to cell growth and cellular senescence. It is important to find a quality-control marker for predicting senescent cells. This study verified that CD47 could be a candidate to select efficient mesenchymal stem cells (MSCs) to enhance the therapeutic effects of stem cell therapy by analyzing the antibody surface array. CD47 expression was significantly decreased during the expansion of MSCs in vitro (p
Databáze: Directory of Open Access Journals
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