| Autor: |
Mohammad Nasir Uddin, Monir Uddin, Md. Touhid Kabir, Suman Das |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Journal of Pure and Applied Chemistry Research, Vol 6, Iss 2, Pp 137-149 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2302-4690 |
| DOI: |
10.21776/ub.jpacr.2017.006.02.318 |
| Popis: |
A new UPLC method has been described to determine ketorolac tromethamine in pharmaceutical samples and biofluids. Drug was eluted using a reversed-phase Gemini 3U, C18, 110R (150 × 4.6 mm, 3 μm) column when a mobile phase composition 90:05:05 (v/v) consisting CH3OH, CH3CN and NaH2PO4 under isocratic program.Ketorolac tromethamine was eluted at a short of time 2.02 min. Ketorolac tromethamine isolated from biofluids after liquid-phase extraction. The results were linear up to 10 µg mL-1 with the correlation coefficients greater than 0.999. The sensitivity limits, LOD and LOQ were 0.016 and 0.051 µg mL-1, respectively. The method is simple, fast and reliable with good specificity and sensitivity and will be suitable for routine analysis of ketorolac tromethamine. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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