Multicellular model of angiogenesis
| Autor: | Takashi Nakazawa, Sohei Tasaki, Kiyohiko Nakai, Takashi Suzuki |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | AIMS Bioengineering, Vol 9, Iss 1, Pp 44-60 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2375-1495 42571693 |
| DOI: | 10.3934/bioeng.2022004?viewType=HTML |
| Popis: | This paper presents a mathematical model governing the dynamics of a morphogenetic vascular endothelial cell (EC) during angiogenesis, and vascular growth formed by EC. Especially, we adopt a multiparticle system for modeling these cells. This model does not distinguish a tip cell from a stalk cell. A formed vessel is modeled using phase-field equation to prevent capillary expansion with time stepping in particular. Numerical simulation reveals that all cells are moving in the direction of high concentration of vascular endothelial growth factor (VEGF), and that they are mutually repellent in cases in which they are closer than some threshold. |
| Databáze: | Directory of Open Access Journals |
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