Synthesis, antibacterial, and antibiofilm activities of pulmonarin B analogues
| Autor: | Liubov Muzychka, Iryna Boiko, Nina Vrynchanu, Oleg Smolii |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Current Chemistry Letters, Vol 13, Iss 2, Pp 335-342 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1927-7296 1927-730X |
| DOI: | 10.5267/j.ccl.2023.11.005 |
| Popis: | New analogues of pulmonarin B were synthesized from (3,5-dibromo-4-hydroxyphenyl)acetic acid derivatives, and their antibacterial and antibiofilm activities against E. coli, S. aureus, and P. aeruginosa were evaluated. The antibacterial activity of synthesized ammonium salts against the methicillin-resistant strain of S. aureus 222 depends on the length of the alkyl chain. Bis-quaternary ammonium salt 5 demonstrated better activity against S. aureus 222, E. coli 311, and P. aeruginosa 449 compared to mono-alkylated derivatives. Analogues of pulmonarin B 5 and 4d reduced S. aureus 222 biofilm formation by 74.5% and 89.4%, respectively. In addition, compound 4c turned out to be the most active against the biofilm formation of P. aeruginosa 449 (biomass decreased by 39.8%). |
| Databáze: | Directory of Open Access Journals |
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