SARS-CoV-2-Triggered Hemophagocytic Lymphohistiocytosis with Complications of Posterior Reversible Encephalopathy Syndrome

Autor: Ross M. Perry, Scott D. Casey, Alex Q. Lee, Sylvia P. Bowditch, Mary A. Rasmussen, Viyeka Sethi, Arun R. Panigrahi
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Case Reports in Pediatrics, Vol 2024 (2024)
Druh dokumentu: article
ISSN: 2090-6811
DOI: 10.1155/2024/8829060
Popis: In this article, we describe a novel case of SARS-CoV-2-associated-hemophagocytic lymphohistiocytosis (HLH) complicated by posterior reversible encephalopathy syndrome (PRES). Initially diagnosed with multisystem inflammatory response in children (MIS-C), the patient received a large corticosteroid dose days before the onset of neurological symptoms. After developing PRES, the patient was treated with antihypertensives, antiepileptics, dexamethasone, and anakinra, leading to neurologic normalization. We propose that given the challenging diagnostic picture of PRES developing in patients with HLH or MIS-C, institutionalized standards for blood pressure management during corticosteroid induction may significantly improve outcomes in patients being treated for hyperinflammatory syndromes who develop neurological symptoms.
Databáze: Directory of Open Access Journals
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