Endocervical Regulatory T Cells Are Associated With Decreased Genital Inflammation and Lower HIV Target Cell Abundance

Autor: Aloysious Ssemaganda, Francois Cholette, Michelle Perner, Cheli Kambaran, Wendy Adhiambo, Peter M. Wambugu, Henok Gebrebrhan, Amy Lee, Faisal Nuhu, Ruth S. Mwatelah, Naima Jahan, Tosin E. Omole, Tabitha Wanjiru, Apollo Gitau, Joshua Kimani, Lyle R. McKinnon
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Immunology, Vol 12 (2021)
Druh dokumentu: article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2021.726472
Popis: Regulatory T cells (Tregs) play important roles in tissue homeostasis, but few studies have investigated tissue Tregs in the context of genital inflammation, HIV target cell density, and vaginal microbiota in humans. In women from Nairobi (n=64), the proportion of CD4+ CD25+ CD127low Tregs in the endocervix correlated with those in blood (r=0.31, p=0.01), with a higher Treg frequency observed in the endocervix (median 3.8 vs 2.0%, p
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