The role of vitamin D in breast cancer

Autor: Tu Tu Aung, Sreenivasa R. Chandana, Karl J. D’Silva, Nikolay V. Dimitrov
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Oncology Reviews, Vol 3, Iss 1 (2011)
Druh dokumentu: article
ISSN: 1970-5557
1970-5565
DOI: 10.4081/oncol.2009.19
Popis: The biological role of vitamin D outside of calcium homeostasis is still under evaluation. The ability of vitamin D to inhibit cell proliferation and induce differentiation makes it a potential modifier of neoplastic transformation. Vitamin D affects the cell cycle, apoptosis, hormone receptors, angiogenesis, and hypoxia, all of which are related to the breast cancer growth, progression and metastasis. A large percentage of the industrial-world population is deficient in vitamin D. Epidemiological evidence suggests that vitamin D deficiency increases the risk of breast cancer. Vitamin D may have synergistic, additive, or antagonistic effects when combined with other therapeutic agents against breast cancer. Vitamin D appears to depress aromatase inhibitor by acting through cytochrome P 450. This evidence along with pre-clinical and clinical studies, justify the inclusion of vitamin D in future clinical trials related to breast cancer in order to determine its efficacy as a part of the breast cancer therapeutic armament.
Databáze: Directory of Open Access Journals
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