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Yang Mei,1,2 Yang Mu,3 Win Wang,2 Bo-Tao Tan,1 Yao-Hua Chen,4 Yu-Ping Li,4 Dan Zhu,4 Wei Li,2 Jian Cui,4 Le-Hua Yu1 1Department of Rehabilitation Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Department of Pain Medicine, Chongqing Hospital of Traditional Chinese Medicine, Chongqing, People’s Republic of China; 3Department of Rehabilitation Medicine, Chongqing University Fuling Hospital, Chongqing, People’s Republic of China; 4Department of Pain Medicine, Southwest Hospital, Army Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Jian Cui; Le-Hua Yu, Email cqjian211@163.com; 300895@cqmu.edu.cnIntroduction: Adenosine 5’-monophosphate (AMP)-activated protein kinase (AMPK) can influence energy metabolism. Energy metabolism imbalance is closely associated with the occurrence of neuropathic pain (NeP). Rs10789038 and rs2796498 are genetic polymorphisms of PRKAA2, the gene encoding AMPK, which is closely related to energy metabolism imbalance. This study aimed to explore the relationship between PRKAA2 and postherpetic neuralgia (PHN) in the southwestern Chinese Han population.Methods: This study enrolled 132 PHN patients and 118 healthy subjects. The rs10789038 and rs2796498 PRKAA2 genotypes were identified in all participants. The association between these single nucleotide polymorphisms and PHN susceptibility was evaluated in the dominant and recessive models. Haplotype analysis of patients with PHN and healthy controls was performed.Results: The PHN patients were older than the healthy subjects (P < 0.05); however, the other clinical characteristics between two groups were not significantly different (all P > 0.05). Genotypes and allele frequencies differed significantly between PHN patients and healthy subjects in the rs10789038 polymorphism (P < 0.05), but not in rs2796498 (P > 0.05). In addition, the GG haplotype of rs10789038-rs2796498 correlated negatively with PHN occurrence in haplotype analysis (P < 0.05).Conclusion: PHN occurrence may be related to the PRKAA2 rs10789038 A>G genetic polymorphism in the southwestern Chinese Han population.Keywords: AMPK, PRKAA2, polymorphism, postherpetic neuralgia |
