| Autor: |
Cihan Heybeli, Mehmet Asi Oktan, Hayri Ustun Arda, Serkan Yildiz, Mehtat Unlu, Caner Cavdar, Aykut Sifil, Ali Celik, Sulen Sarioglu, Taner Camsari |
| Jazyk: |
English<br />Korean |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Kidney Research and Clinical Practice, Vol 38, Iss 2, Pp 186-195 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2211-9132 |
| DOI: |
10.23876/j.krcp.18.0134 |
| Popis: |
Background : P-glycoprotein (P-gp) transports many chemicals that vary greatly in their structure and function. It is normally expressed in renal proximal tubular cells. We hypothesized that P-gp expression influences light chain excretion. Therefore, we investigated whether renal tubular P-gp expression is altered in patients with plasma cell disorders. Methods : We evaluated renal biopsy specimens from patients with plasma cell disorders (n = 16) and primary focal segmental glomerulosclerosis (the control group, n = 17). Biopsies were stained with an anti-P-gp antibody. Loss of P-gp expression was determined semi-quantitatively. Groups were compared for loss of P-gp expression, and clinical variables. Results : P-gp expression loss was more severe in patients with plasma cell disorders than it was in those with glomerulonephritis (P = 0.021). In contrast, clinical and histological parameters including serum creatinine, level of urinary protein excretion, and interstitial fibrosis/tubular atrophy grade were not significantly different between the groups. P-gp expression loss increased with age in patients with plasma cell disorders (P = 0.071). This expression loss was not associated with serum creatinine, the level of urinary protein excretion or the interstitial fibrosis/tubular atrophy grade. There was no significant association between the severity of P-gp expression loss with the types and serum levels of light chains, isotypes and serum immunoglobulin levels. Conclusion : Renal tubular P-gp expression is significantly down-regulated in patients with plasma cell disorders characterized by nephrotic range proteinuria. Additional studies are needed to determine whether reintroduction of renal tubular P-gp expression would mitigate the proximal tubular injury that is caused by free-light chains. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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