| Autor: |
LILYANA WALESKA N. ALBUQUERQUE, SHAKIRA C.A. FERREIRA, IZABELLY CAROLLYNNY M. NUNES, HILDA CAROLINE N. SANTOS, MARIANA S. SANTOS, MÁRCIO THOMAZ S. VARJÃO, AMANDA EVELYN DA SILVA, ANDERSON B. LEITE, ALYSSON W.F. DUARTE, MAGNA SUZANA ALEXANDRE-MOREIRA, ALINE C. DE QUEIROZ |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Anais da Academia Brasileira de Ciências, Vol 96, Iss 3 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1678-2690 |
| DOI: |
10.1590/0001-3764202420230888 |
| Popis: |
Abstract Leishmaniasis is a disease of public health relevance that demands new therapeutic alternatives due to the toxicity of conventional treatments. In this study, 27 plants of interest to the Unified Health System (SUS) were evaluated for cytotoxicity in macrophages, leishmanicidal activity and production of nitric oxide (NO). None of the species demonstrated cytotoxicity to macrophages (CC50 >100 μg/mL). Extracts from Chenopodium ambrosioides, Equisetum arvense, Maytenus ilicifolia showed greater efficacy in inducing the death of Leishmania amazonensis amastigotes with IC50 of 68.4, 82.3, 75.7 μg/mL, respectively. The species Cynara scolymus, Punica granatum and Passiflora alata were the most effective in inducing an increase in the indirect concentration of NO (41.31, 29.30 and 28.86 µM, respectively) in cultures of macrophages infected with L. amazonensis. Furthermore, Punica granatum was also the most effective species in inducing an increase in NO in macrophages infected by Leishmania chagasi (19.90 µM). The results obtained so far support the continuation of studies, with the possibility of developing safer and more effective treatments for leishmaniasis, using natural products. The identification of plants that stimulate the production of NO in macrophages infected by Leishmania opens doors for more detailed investigations of the mechanism of action of these natural products. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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