| Autor: |
Irina Pronina, Svetlana Lukina, Vitaly Loginov, Aleksey Burdennyy, Tatiana Kazubskaya, Eleonora Braga, Elena Filippova |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Medical Sciences Forum, Vol 21, Iss 1, p 7 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2673-9992 |
| DOI: |
10.3390/ECB2023-14083 |
| Popis: |
Breast cancer (BC) remains one of the leading causes of cancer deaths among women worldwide. Recently, studies of long non-coding RNAs (lncRNAs) involved in the regulation of various signaling pathways in cells have become increasingly important, since they demonstrate great prognostic potential in cancer. The aim of our work was to identify new aberrantly expressed lncRNAs in BC. We identified 30 aberrantly expressed lncRNAs in BC. For most lncRNAs, a decrease in the expression level by 2.34–13.2 times (p < 0.05) was noted, and only for lncRNA TERC, an increase in the expression level by 2.24 times (p = 0.034) was noted. Of greatest interest are the data obtained for the lncRNAs ADAMTS9-AS2, EMX2OS, HOTAIRM1 and MEG3, as they are consistent with the data of the bioinformatic analysis. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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