Mandible infiltration as a clinical signal of extramedullary B-cell acute lymphoblastic leukemia/lymphoma in a child: Report of a rare case

Autor: Paulo Victor Mendes Penafort, Lady Paola Aristizabal Arboleda, Sérgio Takashi Kussaba, Izilda Aparecida Cardinalli, Regina Maria Holanda de Mendonça, Márcio Ajudarte Lopes, Pablo Agustin Vargas, Alan Roger Santos-Silva
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Oral Oncology Reports, Vol 9, Iss , Pp 100193- (2024)
Druh dokumentu: article
ISSN: 2772-9060
DOI: 10.1016/j.oor.2024.100193
Popis: B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) is a type of malignancy involving uncontrolled proliferation of B-precursor lymphoid cells. This case report delineates B-cell lymphoblastic leukemia/lymphoma (B-ALL/LBL) manifesting in the mandible and medullary regions of a 10-year-old female. Clinically, an irregular swelling with bone cortical destruction and weight loss was observed. Histopathological examination revealed proliferation of CD10, CD43, CD79a, PAX-5, TDT, CD99, and FLI-1 positive small round blue cells, with a 49% lymphoblast infiltration in the bone marrow. Chemotherapy was administered, leading to disease control during the 5-year follow-up.
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