| Autor: |
Jonny Karunia Fajar, Budi Susetio Pikir, Erdo Puncak Sidarta, Putu Nina Berlinda Saka, Rizal Rahmanda Akbar, Teuku Heriansyah |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Indian Heart Journal, Vol 71, Iss 3, Pp 199-206 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
0019-4832 |
| DOI: |
10.1016/j.ihj.2019.07.002 |
| Popis: |
Objectives: The aim of the study was to evaluate the correlation between left ventricular hypertrophy and the gene polymorphism of angiotensin-converting enzyme (ACE) intron deletion (I/D) and ACE G2350A. Methods: Information related to the sample size and genotype frequencies was extracted from each study. Results: Our results found that the D allele (p = 0.0180) and DD genotype (p = 0.0110) of ACE I/D had a significant association with increasing the risk of left ventricular hypertrophy, whereas the I allele (p = 0.0180), but not II (p = 0.1660) and ID genotypes (p = 0.1430), was associated with decreasing the risk of left ventricular hypertrophy. On other hand, we found that the A allele (p = 0.0020) and GA genotype of ACE G2350A (p = 0.0070) had the correlation with increasing the risk of left ventricular hypertrophy. Conclusions: Our meta-analysis reveals that the D allele of ACE I/D and the A allele of ACE G2350A are associated with increasing the risk of left ventricular hypertrophy. Keywords: Left ventricular hypertrophy, Angiotensin-converting enzyme, ACE I/D, ACE G2350A |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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