| Autor: |
Sircoulomb Fabrice, Birnbaum Daniel, Imbert Jean |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Cancer Cell International, Vol 9, Iss 1, p 5 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1475-2867 |
| DOI: |
10.1186/1475-2867-9-5 |
| Popis: |
Abstract Alterations of receptor-type tyrosine kinases (RTK) are frequent in human cancers. They can result from translocation, mutation or amplification. The ERBB2 RTK is encoded by a gene that is amplified in about 20% breast cancers. The question is: why is this RTK specifically subjected to this type of alteration? We propose that ERBB2 gene amplification is used to overcome repression of its expression by sequence-specific transcription factors. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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