Effects Of Amitryptilin Administration on Rat Sera and Brain Beta-endorphins

Autor:	Radivoj Jadrić, Sabaheta Hasić, Emina Kiseljaković, Jovan Radovanović, Emina Ićindić-Nakaš, Mira Winterhalter-Jadrić
Jazyk:	angličtina
Rok vydání:	2006
Předmět:	amitryptilin beta-endorphins rat sera brain Biology (General) QH301-705.5
Zdroj:	Biomolecules & Biomedicine, Vol 6, Iss 4 (2006)
Druh dokumentu:	article
ISSN:	2831-0896 2831-090X
DOI:	10.17305/bjbms.2006.3124
Popis:	The aim of our study was to establish the influence of antidepressive drugs on serum and brain beta-endorphins in experimental animals. Experiment was performed on albino Wistar rats. Antidepressant amitryptiline was used, and for quantification of sera and brain beta-endorphins RIA technique. Our results showed difference between sera and brain beta-endorphins concentration in amitryptiline pretreated animals, vs. those in serum and brain of control group treated with 0.95% NaCl. This study shows that use of psychoactive drugs have influence on sera and brain beta-endorphins concentration. Beta-endorphins could be of great importance, used as markers for evaluation of antidepressant drug effects.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/48d038aaa4b1420cbe49c64378c366c0 Zobrazit plný text záznamu View record in DOAJ