| Autor: |
Samuel Thomas Jones, Monica Londahl, Anthony Prothero, FD Richard Hobbs, Ian Pavord, Saul G Myerson, Bernard D Prendergast, Sean Coffey |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
BJGP Open, Vol 7, Iss 1 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2398-3795 |
| DOI: |
10.3399/BJGPO.2022.0105 |
| Popis: |
Background: During left-sided heart failure (HF), left atrial and pulmonary venous pressure increase, which may lead to pulmonary congestion. Previous cohort studies, examining participants with symptomatic HF or rheumatic heart disease, suggest a relationship between increased left atrial pressure (LAP) and fractional exhaled nitric oxide (FeNO). Aim: To examine the strength of association between FeNO and echocardiographic assessment of LAP by the E/e’ ratio, to determine if FeNO could be used to identify those with elevated LAP. Design & setting: This cross-sectional cohort study examined a subset of the OxVALVE cohort aged ≥65 years. Data collection was undertaken in primary care practices in central England. Method: Each participant underwent a focused cardiovascular history and clinical examination. Standard transthoracic echocardiographic (TTE) assessment was performed on all participants, with the E/e’ ratio calculated to obtain a validated surrogate of LAP. FeNO was measured in 227 participants. Results: FeNO was higher in males compared with females and no different in participants with asthma, chronic obstructive pulmonary disease (COPD), or those using inhaled steroids. Participants with a high E/e’ (>14) were older, with a higher proportion of females than males. There was no relationship between E/e’ and FeNO, either when measured as a continuous variable or in the group with high E/e’. Conclusion: FeNO was not found to be an accurate predictor of elevated LAP in a primary care setting. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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