| Autor: |
Satoshi Bujo, Haruhiro Toko, Kaoru Ito, Satoshi Koyama, Masato Ishizuka, Masahiko Umei, Haruka Yanagisawa-Murakami, Jiaxi Guo, Bowen Zhai, Chunxia Zhao, Risa Kishikawa, Norifumi Takeda, Kensuke Tsushima, Yuichi Ikeda, Eiki Takimoto, Hiroyuki Morita, Mutsuo Harada, Issei Komuro |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-30821-7 |
| Popis: |
Abstract Cardiovascular disease (CVD) is a global health burden in the world. Although low-carbohydrate diets (LCDs) have beneficial effects on CVD risk, their preventive effects remain elusive. We investigated whether LCDs ameliorate heart failure (HF) using a murine model of pressure overload. LCD with plant-derived fat (LCD-P) ameliorated HF progression, whereas LCD with animal-derived fat (LCD-A) aggravated inflammation and cardiac dysfunction. In the hearts of LCD-P-fed mice but not LCD-A, fatty acid oxidation-related genes were highly expressed, and peroxisome proliferator-activated receptor α (PPARα), which regulates lipid metabolism and inflammation, was activated. Loss- and gain-of-function experiments indicated the critical roles of PPARα in preventing HF progression. Stearic acid, which was more abundant in the serum and heart of LCD-P-fed mice, activated PPARα in cultured cardiomyocytes. We highlight the importance of fat sources substituted for reduced carbohydrates in LCDs and suggest that the LCD-P-stearic acid-PPARα pathway as a therapeutic target for HF. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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