| Autor: |
Rabiat Unekwu Hamzah, Alli Abdullahi Jigam, Hussaini Anthony Makun, Evans Chidi Egwim, Hadiza Lami Muhammad, Musa Bola Busari, Gabriel Femi Ibikunle, Sulaiman Kolapo Abubakar-Akanbi |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Integrative Medicine Research, Vol 7, Iss 2, Pp 149-158 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2213-4220 |
| DOI: |
10.1016/j.imr.2018.01.004 |
| Popis: |
Background: This study was designed to determine the hepatoprotective effect of partially purified fractions from Pterocarpus mildbraedii extract on carbon tetrachloride (CCl4) intoxicated rats. Methods: The methanol extract of P. mildbraedii was subjected to solvent partitioning using n-hexane, chloroform, ethylacetate and water. Separation of fractions with proven antioxidant activity was achieved by chromatographic techniques. Acute toxicity and hepatoprotective studies of the methanol sub-fraction 6 (Me 6), methanol sub-fraction 7 (Me 7) and methanol sub-fraction 8 (Me 8) from P. mildbraedii extract on carbon tetrachloride (CCl4) intoxicated Wister rats. Results: Intoxication of rats with CCl4 resulted in significant (p 0.05) in the activities of the liver enzymes, MDA level, total and direct bilirubin in dose-dependent manner. There were significant (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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