Comprehensive microRNA analysis identifies miR-24 and miR-125a-5p as plasma biomarkers for rheumatoid arthritis.

Autor: Koichi Murata, Moritoshi Furu, Hiroyuki Yoshitomi, Masahiro Ishikawa, Hideyuki Shibuya, Motomu Hashimoto, Yoshitaka Imura, Takao Fujii, Hiromu Ito, Tsuneyo Mimori, Shuichi Matsuda
Jazyk: angličtina
Rok vydání: 2013
Předmět:
Zdroj: PLoS ONE, Vol 8, Iss 7, p e69118 (2013)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0069118
Popis: MicroRNAs (miRNAs) are present in human plasma and known as a non-invasive biomarker for cancer detection. Our study was designed to identify plasma miRNAs specific for rheumatoid arthritis (RA) by a comprehensive array approach. We performed a systematic, array-based miRNA analysis on plasma samples from three RA patients and three healthy controls (HCs). Plasma miRNAs with more than four times change or with significant (P
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