| Autor: |
Joshua Tam, PhD, Ying Wang, MD, William A. Farinelli, BA, Joel Jiménez-Lozano, PhD, Walfre Franco, PhD, Fernanda H. Sakamoto, MD, PhD, Evelyn J. Cheung, MD, Martin Purschke, PhD, Apostolos G. Doukas, PhD, R. Rox Anderson, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Plastic and Reconstructive Surgery, Global Open, Vol 1, Iss 6, p e47 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
2169-7574 |
| DOI: |
10.1097/GOX.0b013e3182a85a36 |
| Popis: |
Background: Conventional autologous skin grafts are associated with significant donor-site morbidity. This study was conducted to determine feasibility, safety, and efficacy of a new strategy for skin grafting based on harvesting small columns of full-thickness skin with minimal donor-site morbidity. Methods: The swine model was used for this study. Hundreds of full-thickness columns of skin tissue (~700 µm diameter) were harvested using a custom-made harvesting device, and then applied directly to excisional skin wounds. Healing in donor and graft sites was evaluated over 3 months by digital photographic measurement of wound size and blinded, computer-aided evaluation of histological features and compared with control wounds that healed by secondary intention or with conventional split-thickness skin grafts (STSG). Results: After harvesting hundreds of skin columns, the donor sites healed rapidly without scarring. These sites reepithelialized within days and were grossly and histologically indistinguishable from normal skin within 7 weeks. By contrast, STSG donor sites required 2 weeks for reepithelialization and retained scar-like characteristics in epidermal and dermal architecture throughout the experiment. Wounds grafted with skin columns resulted in accelerated reepithelialization compared with ungrafted wounds while avoiding the “fish-net” patterning caused by STSG. Conclusion: Full-thickness columns of skin can be harvested in large quantities with negligible long-term donor-site morbidity, and these columns can be applied directly to skin wounds to enhance wound healing. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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