| Autor: |
Arham Ihtesham, Shahzaib Maqbool, Muhammad Nadeem, Muhammad Bilawal Abbas Janjua, Omaima Sundus, Ali Bakht Naqqash, Waleed Inayat Mohamed, Syed Turab Haider, Muhmmad Ahmad, Mir Ahmad Talha Mustafa, Hafiz Osama Mehboob |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
AIMS Microbiology, Vol 7, Iss 3, Pp 284-303 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2471-1888 |
| DOI: |
10.3934/microbiol.2021018?viewType=HTML |
| Popis: |
Immune thrombocytopenic purpura (ITP) is an autoimmune disease characterised by production of autoantibodies against platelet surface antigens. Recent studies have demonstrated a paramount association of ITP and Helicobacter pylori (H-pylori) infection with significant rise in platelet count following H-pylori eradication therapy. The H-pylori infection induced ITP is validated by many proposed mechanisms such as molecular mimicry due to production of autoantibodies against H-pylori surface virulent factors (CagA) and cross reactivity of these antibodies with platelet surface antigens (GP IIb/IIIa, GP Ib/IX, and GP Ia/IIa), phagocytic perturbation due to enhanced phagocytic activity of monocytes, enhanced dendritic cell numbers and response, platelets aggregation due to presence of anti- H-pylori IgG and von Willebrand factor (vWf) and finally host immune response against H-pylori virulent factors CagA and VacA leading to ITP. The effectiveness of H-pylori eradication therapy has also been demonstrated with platelet count being used as a predictive factor for assessment of treatment efficacy. Out of 201 patients 118 were responding to the triple therapy and remaining 83 patients were non-responders, showing the response rate of 58.7%. Out of 118 responders 69 patients were showing complete response (CR) and 49 were showing partial response (PR) to the H-pylori eradication therapy. However, more studies are required to elucidate this association and treatment efficacy. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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