Efficacy of short period, low dose oral prednisolone for the prevention of stricture after circumferential endoscopic submucosal dissection (ESD) for esophageal cancer

Autor: Mikinori Kataoka, Sho Anzai, Tomoaki Shirasaki, Hidekazu Ikemiyagi, Takashi Fujii, Kazuhisa Mabuchi, Shinji Suzuki, Masashi Yoshida, Takashi Kawai, Masaki Kitajima
Jazyk: angličtina
Rok vydání: 2015
Předmět:
Zdroj: Endoscopy International Open, Vol 03, Iss 02, Pp E113-E117 (2015)
Druh dokumentu: article
ISSN: 2364-3722
2196-9736
DOI: 10.1055/s-0034-1390797
Popis: Background and aims: Endoscopic submucosal dissection (ESD) was developed in Japan and has been performed on many patients with early stage esophageal cancer; however quality of life in patients with postoperative stricture is drastically decreased and repeat, periodic endoscopic balloon dilatation (EBD) is usually required over long periods. In this study, we evaluate the efficacy of short period, low dose oral prednisolone in controlling post-procedural esophageal stricture. Patients and methods: In total, 33 patients who underwent semicircular or complete circular ESD for esophageal superficial squamous cell carcinoma were included in this study. They were divided into two groups: those who underwent large-circumference ESD with no preventative treatment for stricture (ESD alone group) and those who received systemic steroid treatment for stricture (oral prednisolone group). We compared the two groups in terms of stricture rate and total number of EBD sessions. The ESD alone group underwent no preventative treatment. The oral prednisolone group started with 30 mg/day prednisolone on the second day post-ESD, and continued with a gradually tapering prednisolone dose, finally discontinuing systemic steroid administration 3 weeks later. Results: The stricture rate after ESD was significantly lower in the oral prednisolone group (3 of 17 patients; 17.6 %) than in the ESD alone group (11 of 16 patients; 68.7 %) (P
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