| Autor: |
Catherine Hyams, Robert Challen, Robin Marlow, Jennifer Nguyen, Elizabeth Begier, Jo Southern, Jade King, Anna Morley, Jane Kinney, Madeleine Clout, Jennifer Oliver, Sharon Gray, Gillian Ellsbury, Nick Maskell, Luis Jodar, Bradford Gessner, John McLaughlin, Leon Danon, Adam Finn, Amelia Langdon, Anabella Turner, Anya Mattocks, Bethany Osborne, Charli Grimes, Claire Mitchell, David Adegbite, Emma Bridgeman, Emma Scott, Fiona Perkins, Francesca Bayley, Gabriella Ruffino, Gabriella Valentine, Grace Tilzey, James Campling, Johanna Kellett Wright, Julia Brzezinska, Julie Cloake, Katarina Milutinovic, Kate Helliker, Katie Maughan, Kazminder Fox, Konstantina Minou, Lana Ward, Leah Fleming, Leigh Morrison, Lily Smart, Louise Wright, Lucy Grimwood, Maddalena Bellavia, Marianne Vasquez, Maria Garcia Gonzalez, Milo Jeenes-Flanagan, Natalie Chang, Niall Grace, Nicola Manning, Oliver Griffiths, Pip Croxford, Peter Sequenza, Rajeka Lazarus, Rhian Walters, Robyn Heath, Rupert Antico, Sandi Nammuni Arachchge, Seevakumar Suppiah, Taslima Mona, Tawassal Riaz, Vicki Mackay, Zandile Maseko, Zoe Taylor, Zsolt Friedrich, Zsuzsa Szasz-Benczur |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
The Lancet Regional Health. Europe, Vol 25, Iss , Pp 100556- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2666-7762 |
| DOI: |
10.1016/j.lanepe.2022.100556 |
| Popis: |
Summary: Background: There is an urgent public health need to evaluate disease severity in adults hospitalised with Delta and Omicron SARS-CoV-2 variant infections. However, limited data exist assessing severity of disease in adults hospitalised with Omicron SARS-CoV-2 infections, and to what extent patient-factors, including vaccination, age, frailty and pre-existing disease, affect variant-dependent disease severity. Methods: A prospective cohort study of adults (≥18 years of age) hospitalised with acute lower respiratory tract disease at acute care hospitals in Bristol, UK conducted over 10-months. Delta or Omicron SARS-CoV-2 infection was defined by positive SARS-CoV-2 PCR and variant identification or inferred by dominant circulating variant. We constructed adjusted regression analyses to assess disease severity using three different measures: FiO2 >28% (fraction inspired oxygen), World Health Organization (WHO) outcome score >5 (assessing need for ventilatory support), and hospital length of stay (LOS) >3 days following admission for Omicron or Delta infection. Findings: Independent of other variables, including vaccination, Omicron variant infection in hospitalised adults was associated with lower severity than Delta. Risk reductions were 58%, 67%, and 16% for supplementary oxygen with >28% FiO2 [Relative Risk (RR) = 0.42 (95%CI: 0.34–0.52), P 5 [RR = 0.33 (95%CI: 0.21–0.50), P 3 days [RR = 0.84 (95%CI: 0.76–0.92), P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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