| Autor: |
Floris L. van Delft, Floris P.J.T. Rutjes, Gerard W. Canters, Alessio Andreoni, Leandro C. Tabares, M. Waqar Aslam |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Pharmaceuticals, Vol 3, Iss 3, Pp 679-701 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1424-8247 |
| DOI: |
10.3390/ph3030679 |
| Popis: |
A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity with a unique hemocyanin-based biosensor. Based on the outcome of these results, a second-generation set of monomeric conjugates was prepared and found to display significant antibacterial activity, in particular with respect to kanamycin-resistant E. coli. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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