HIV-1 Replication and the Cellular Eukaryotic Translation Apparatus

Autor:	Santiago Guerrero, Julien Batisse, Camille Libre, Serena Bernacchi, Roland Marquet, Jean-Christophe Paillart
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	HIV-1 translation auxiliary proteins IRES leaky-scanning frameshift ribosome shunting Microbiology QR1-502
Zdroj:	Viruses, Vol 7, Iss 1, Pp 199-218 (2015)
Druh dokumentu:	article
ISSN:	1999-4915 68814933
DOI:	10.3390/v7010199
Popis:	Eukaryotic translation is a complex process composed of three main steps: initiation, elongation, and termination. During infections by RNA- and DNA-viruses, the eukaryotic translation machinery is used to assure optimal viral protein synthesis. Human immunodeficiency virus type I (HIV-1) uses several non-canonical pathways to translate its own proteins, such as leaky scanning, frameshifting, shunt, and cap-independent mechanisms. Moreover, HIV-1 modulates the host translation machinery by targeting key translation factors and overcomes different cellular obstacles that affect protein translation. In this review, we describe how HIV-1 proteins target several components of the eukaryotic translation machinery, which consequently improves viral translation and replication.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/487e8e2a688149339a0a02e18910b89d Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF