Comparison and impact of COVID-19 for patients with cancer: a survival analysis of fatality rate controlling for age, sex and cancer type

Autor: Xiang Zhang, Haiquan Li, Charles L Bennett, Edwin Baldwin, Colleen Kenost, Wenting Luo, Elizabeth A Calhoun, Lingling An, Yves A Lussier
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: BMJ Health & Care Informatics, Vol 28, Iss 1 (2021)
Druh dokumentu: article
ISSN: 2632-1009
DOI: 10.1136/bmjhci-2021-100341
Popis: Objectives Prior research has reported an increased risk of fatality for patients with cancer, but most studies investigated the risk by comparing cancer to non-cancer patients among COVID-19 infections, where cancer might have contributed to the increased risk. This study is to understand COVID-19’s imposed HR of fatality while controlling for covariates, such as age, sex, metastasis status and cancer type.Methods We conducted survival analyses of 4606 cancer patients with COVID-19 test results from 16 March to 11 October 2020 in UK Biobank and estimated the overall HR of fatality with and without COVID-19 infection. We also examined the HRs of 13 specific cancer types with at least 100 patients using a stratified analysis.Results COVID-19 resulted in an overall HR of 7.76 (95% CI 5.78 to 10.40, p
Databáze: Directory of Open Access Journals