CCN1 is an opsonin for bacterial clearance and a direct activator of Toll-like receptor signaling

Autor: Joon-Il Jun, Lester F. Lau
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-15075-5
Popis: CCN1 is a matricellular protein with a variety of functions, including an effect on wound healing and an association with inflammation. Here, the authors identify a possible mechanism by showing that CCN1 mediates the clearance of bacterial infections in mice and activates TLR signalling.
Databáze: Directory of Open Access Journals