| Autor: |
Cheuk-Chun Szeto, Jack Kit-Chung Ng, Winston Wing-Shing Fung, Cathy Choi-Wan Luk, Gang Wang, Kai-Ming Chow, Ka-Bik Lai, Philip Kam-Tao Li, Fernand Mac-Moune Lai |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Kidney Medicine, Vol 3, Iss 1, Pp 76-82.e1 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0595 |
| DOI: |
10.1016/j.xkme.2020.11.009 |
| Popis: |
Rationale & Objective: Previous studies have suggested that microRNA-21 (miR-21) plays an important role in kidney fibrosis. We examined the relationship between intrarenal miR-21 level and rate of kidney function loss in immunoglobulin A nephropathy (IgAN). Study Design: Prospective cohort study. Setting & Participants: 40 patients with IgAN and 10 with hypertensive nephrosclerosis as controls. Predictors: miR-21 levels in kidney biopsy specimen and urinary sediment, quantified as ratio to the housekeeping gene. Outcomes: Kidney event–free survival and rate of kidney function decline. Analytic Approach: Time-to-event and correlation analysis. Results: The IgAN group had significantly higher intrarenal miR-21 expression compared with the hypertensive nephrosclerosis group (1.71 [IQR, 0.99-2.77] vs 0.31 [IQR, 0.25-1.32]; P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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