| Autor: |
Pankaj Ahluwalia, Ashis K. Mondal, Meenakshi Ahluwalia, Nikhil S. Sahajpal, Kimya Jones, Yasmeen Jilani, Gagandeep K. Gahlay, Amanda Barrett, Vamsi Kota, Amyn M. Rojiani, Ravindra Kolhe |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Cancer Medicine, Vol 11, Iss 6, Pp 1573-1586 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-7634 |
| DOI: |
10.1002/cam4.4568 |
| Popis: |
Abstract Understanding the complex tumor microenvironment is key to the development of personalized therapies for the treatment of cancer including colorectal cancer (CRC). In the past decade, significant advances in the field of immunotherapy have changed the paradigm of cancer treatment. Despite significant improvements, tumor heterogeneity and lack of appropriate classification tools for CRC have prevented accurate risk stratification and identification of a wider patient population that may potentially benefit from targeted therapies. To identify novel signatures for accurate prognostication of CRC, we quantified gene expression of 12 immune‐related genes using a medium‐throughput NanoString quantification platform in 93 CRC patients. Multivariate prognostic analysis identified a combined four‐gene prognostic signature (TGFB1, PTK2, RORC, and SOCS1) (HR: 1.76, 95% CI: 1.05–2.95, *p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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