Optical Microsphere Nano-Imaging: Progress and Challenges

Autor: Guangxing Wu, Minghui Hong
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Engineering, Vol 36, Iss , Pp 102-123 (2024)
Druh dokumentu: article
ISSN: 2095-8099
DOI: 10.1016/j.eng.2023.10.019
Popis: The optical diffraction effect imposes a radical obstacle preventing conventional optical microscopes from achieving an imaging resolution beyond the Abbe diffraction limit and thereby restricting their usage in a multitude of nanoscale applications. Over the past decade, the optical microsphere nano-imaging technique has been demonstrated to be a cost-effective solution for overcoming the diffraction limit and has achieved an imaging resolution of up to about λ6-λ8 in a real-time and label-free manner, making it highly competitive among numerous super-resolution imaging technologies. In this review, we summarize the underlying nano-imaging mechanisms of the microsphere nanoscope and key advancements aimed at imaging performance enhancement: first, to change the working environment or modify the peripheral hardware of a single microsphere nanoscope at the system level; second, to compose the microsphere compound lens; and third, to engineer the geometry or ingredients of microspheres. We also analyze challenges yet to be overcome in optical microsphere nano-imaging, followed by an outlook of this technique.
Databáze: Directory of Open Access Journals