| Autor: |
I Ketut Suyasa, Anak Agung Wiradewi Lestari |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Chinese Journal of Traumatology, Vol 23, Iss 2, Pp 107-112 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1008-1275 |
| DOI: |
10.1016/j.cjtee.2019.09.003 |
| Popis: |
Purpose: Severe damage to the femoral head in patients with osteonecrosis has a high impact on morbidity. Despite early diagnosis, the treatment outcome is still unsatisfactory. This study aimed to explore the expression of vascular endothelial growth factor (VEGF) and cyclic guanine monophosphate (cGMP) serum level as the risk factors of femoral head osteonecrosis in alcohol-exposed Wistar rats. Methods: This was an experimental study using randomized post-test only control group design, with samples using 10–14 weeks Wistar male rats. Rats were then divided into 6 groups: 3 groups without intervention, and 3 groups with intervention using 40% alcohol given perorally. Each one group from intervention and control group was euthanized by the end of the week for 3 consecutive weeks. Proximal femurs were examined under microscope for osteonecrosis, immunohistochemically for VEGF, and blood serum for cGMP levels. Results: VEGF expression in the femoral head of alcohol-exposed Wistar rats was lower than those not exposed to alcohol (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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