| Autor: |
Daniela Giunta, PhD, Antonio Arras, Paola Peluso, Maurizio Solinas |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 3, Iss , Pp 100122- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2021.100122 |
| Popis: |
Two new chiral “click BOX” ligands have been synthetised with high yields starting from commercially available dimethyl propargylmalonate and optically pure alkanolamines, followed by copper catalysed cycloaddition (CuAAC) and oxazoline ring formation. Catalytic activity of the new ligands has been tested in the copper mediated Henry addition. The model reaction between nitromethane and o-anisaldehyde affords the related 1-(2-methoxyphenyl)-2-nitroethanol in high yields (up to 92%) and moderate enantioselectivities (up to 67% e.e.) under straightforward experimental conditions. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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