Overexpression of neuregulin 1 in GABAergic interneurons results in reversible cortical disinhibition

Autor: Yao-Yi Wang, Bing Zhao, Meng-Meng Wu, Xiao-Li Zheng, Longnian Lin, Dong-Min Yin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-20552-y
Popis: The molecular and cellular mechanisms of cortical disinhibition as a common feature of many psychiatric diseases are not fully understood. The authors identify an interaction between NRG1 and Nav1.1 sodium channel as a mechanism of how NRG1 modulates the excitability of GABAergic interneurons.
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