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Min Xi,1 Gang Zhang,1 Liang Wang,2 Hu Chen,2 Li Gao,2 Luyi Zhang,1 Zhangkai Yang,1 Hangyu Shi1 1Department of Neurosurgery, Xi’an Children’s Hospital, Xi’an, 710043, People’s Republic of China; 2Department of Neurosurgery, Tangdu Hospital, Air Force Medical University, Xi’an, 710038, People’s Republic of ChinaCorrespondence: Hangyu Shi, Department of Neurosurgery, Xi’an Children’s Hospital, #69, Xijuyuan Lane, Lianhu District, Xi’an, 710043, Shaanxi, People’s Republic of China, Tel/Fax +86-15202910508, Email shihangyu723@aliyun.comBackground: This study aimed to evaluate the relationship between CARMN polymorphisms and glioma risk and prognosis in a Chinese Han population.Methods: Seven single nucleotide polymorphisms (SNPs) in CARMN were genotyped among 592 glioma patients and 502 healthy controls. Log-additive models were used for risk assessment by the odds ratios (ORs) and 95% confidence intervals (CIs). Univariate and multivariate Cox regression analysis was applied to calculate Hazard ratios (HRs) and 95% CIs for prognosis assessment.Results: CARMN rs13177623 was a protective factor for glioma susceptibility (OR = 0.78, p = 0.043). In addition, rs13177623, rs11168100, rs12654195 and rs17796757 were associated with the risk of glioma among the subgroup stratified by age or gender. We also found that G rs13177623G rs12654195 haplotype was related to the decreased risk of glioma (OR = 0.61, p = 0.005). Importantly, rs13177623 [overall survival (OS): HR = 0.83, p = 0.047, and progression free survival (PFS): HR = 0.82, p = 0.031], rs12654195 (OS: HR = 0.64, p = 0.005 and PFS: HR = 0.65, p = 0.007) and rs11168100 (OS: HR = 0.71, p = 0.035) were associated with a better prognosis for glioma, especially in grade I-II glioma. In patients with grade III-IV glioma, rs17796757 polymorphism presented an improved OS.Conclusion: Our results firstly reported the contribution of CARMN variants (rs11168100, rs12654195, rs13177623, and rs17796757) to the susceptibility and prognosis of glioma in a Chinese Han population, which provided a novel insight on the relationship between CARMN gene and glioma tumorigenesis.Keywords: glioma, CARMN variants, susceptibility, prognosis, genetic variations |
