Real-Time Light-Guided Vocal Fold Injection: An In Vivo Feasibility Study in a Canine Model
| Autor: | Hee Young Son, Sanghoon Kim, Ramla Talib Mohammad, Gene Huh, Hyojin Kim, Woo-Jin Jeong, Wonjae Cha |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Otorhinolaryngology, Vol 14, Iss 3, Pp 338-346 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1976-8710 2005-0720 |
| DOI: | 10.21053/ceo.2020.02180 |
| Popis: | Objectives The transcutaneous approach is a good option for office-based vocal fold injection (VFI). However, precise localization requires extensive experience because the needle tip is invisible in small and complex laryngeal spaces. Recently, real-time light-guided VFI (RL-VFI) was proposed as a new technique that allows simultaneous injection under precise needle localization by light guidance. Herein, we aimed to verify the feasibility of RL-VFI in an in vivo canine model and explored its clinical usefulness. Methods The device for RL-VFI comprised a light source (light-emitting diode modules [10 W] of red color [650 nm]) and injectors (1.5 inches, 23 gauge). An adult male beagle was used for the experiment. After tracheostomy, a rigid laryngoscope was inserted and suspended to expose the larynx. A flexible naso-laryngoscopy system was used to visualize the vocal folds. Results RL-VFI was performed using various transcutaneous approaches, including the cricothyroid, transthyroid, and transhyoid approaches. Light guidance helped identify the path of the needle and prevent inadvertent penetration. The location of the needle tip was accurately indicated by the light. The illuminated needle could be easily placed at the intended points in the vocal fold with real-time visual-motor feedback. Hyaluronic acid could be simultaneously injected lateral to the vocal process under light guidance without manipulation of the device. Conclusion RL-VFI was found to be safe and feasible in an in vivo canine model, providing precise localization and visual-motor feedback. The clinical application of RL-VFI is expected to improve the safety and precision of VFI. |
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