Establishment of the HPLC fluorescence detection method for plasma trace ivermectin and its pharmacokinetics in Bactrian camel

Autor:	Bin Hou, Haifeng Wang, Nan Jiang, Bilige Haosi, Surong Hasi
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Bactrian camel ivermectin injection HPLC fluorescence detection pharmacokinetic characteristics Veterinary medicine SF600-1100
Zdroj:	Veterinary Medicine and Science, Vol 10, Iss 3, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2053-1095
DOI:	10.1002/vms3.1447
Popis:	Abstract Background and objective Ivermectin (IVM), a widely used veterinary anthelmintic, lacks recommended doses for Bactrian camels. This study aims to establish its pharmacokinetics in Bactrian camels, comparing with other livestock. Methods A method for high‐performance liquid chromatography fluorescence detection of IVM in plasma was developed. Results IVM exhibited linear scaling (y = 0.6946x + 0.0088, R2 = 0.9988) within 0.025–5 ng/mL, with a lower limit of quantification of 25.00 pg/mL, high recovery (>70%) and low RSD (
Databáze:	Directory of Open Access Journals
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