Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation

Autor: Janet Berrios, Alice M. Stamatakis, Pranish A. Kantak, Zoe A. McElligott, Matthew C. Judson, Megumi Aita, Marie Rougie, Garret D. Stuber, Benjamin D. Philpot
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-8 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms10702
Popis: Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation.
Databáze: Directory of Open Access Journals