Establishing Normal Serum Values of Neurofilament Light Chains and Glial Fibrillary Acidic Protein Considering the Effects of Age and Other Demographic Factors in Healthy Adults

Autor: Alexander Rodero-Romero, Enric Monreal, Raquel Sainz-Amo, José Manuel García Domínguez, Noelia Villarrubia, Jose Luís Veiga-González, José Ignacio Fernández-Velasco, Haydee Goicochea-Briceño, Fernando Rodríguez-Jorge, Susana Sainz de la Maza, Juan Luís Chico-García, Alfonso Muriel, Jaime Masjuan, Lucienne Costa-Frossard, Luisa María Villar
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 25, Iss 14, p 7808 (2024)
Druh dokumentu: article
ISSN: 1422-0067
1661-6596
DOI: 10.3390/ijms25147808
Popis: Multiple studies have shown the importance of blood-based biomarkers indicating axonal damage (serum neurofilament light chains [sNfL]) or astroglia activation (serum glial fibrillary acidic protein [sGFAP]) for monitoring different neurological diseases. However, normal values of these variables remain to be clearly defined, partly due to the influence of different demographic factors. We investigated demographic differences in a cohort of healthy volunteers. A cross-sectional study was conducted including 116 healthy controls with ages between 18 and 69 years (67.5% females; n = 79). sNfL and sGFAP concentrations were measured using single-molecule arrays. Age and body mass index affected sNfL values, and age was found to be the most important factor. The normal values changed with age, and we established normal values for individuals younger than 45 years as
Databáze: Directory of Open Access Journals
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