Efficacy and safety of tirofiban injection with intracranial stenting in early reocclusion due to intracranial atherosclerosis

Autor: Yun Ho Noh, Ji Young Lee, Seok Mann Yoon, Yu Jin Ha, Jaewoo Chung, Jung Ho Ko, Dong Seong Shin, Jae-Min Ahn, Hyuk Jin Oh, Jai-Joon Shim, Man Ryul Lee, Jae Sang Oh
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Interdisciplinary Neurosurgery, Vol 27, Iss , Pp 101425- (2022)
Druh dokumentu: article
ISSN: 2214-7519
DOI: 10.1016/j.inat.2021.101425
Popis: Objective: We aimed to develop an optimal protocol for failed mechanical thrombectomy (MT) in cases of emergent large vessel occlusion (ELVO) with intracranial atherosclerosis (ICAS). Methods: A total of 117 patients without underlying heart disease who were not taking antiplatelet drugs had early reocclusion during MT for ELVO due to ICAS. They were divided into the following 3 groups according to rescue treatment methods: 1) Combined intravenous (IV) + intra-arterial (IA) tirofiban group (n = 48), emergent percutaneous transluminal angioplasty (PTA) and intracranial stenting (ICS) followed by IA injection of tirofiban and a continuous IV tirofiban infusion for 8 h; 2) IA tirofiban group (n = 33), only IA 0.5–1.0 mg tirofiban infusion for 5 min regardless of PTA or ICS; and 3) no tirofiban group (n = 36), no tirofiban injection regardless of PTA or ICS. Results: ICS was more frequently performed in the combined IV + IA tirofiban group than in the IA tirofiban group (100% vs 46%, p
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