The effectiveness and outcomes of epidural analgesia in patients undergoing open liver resection: a propensity score matching analysis

Autor: Isarapong Pianngarn, Worakitti Lapisatepun, Maytinee Kulpanun, Anon Chotirosniramit, Sunhawit Junrungsee, Warangkana Lapisatepun
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Anesthesiology, Vol 24, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 1471-2253
DOI: 10.1186/s12871-024-02697-1
Popis: Abstract Background Open liver resection necessitates a substantial upper abdominal inverted-L incision, resulting in severe pain and compromising patient recovery. Despite the efficacy of epidural analgesia in providing adequate postoperative analgesia, the potential epidural-related adverse effects should be carefully considered. This study aims to compare the efficacy and safety of continuous epidural analgesia and intravenous analgesia in open liver resection. Methods A retrospective study was conducted, collecting data from patients who underwent open liver resection between 2007 and 2017. Propensity score matching was implemented to mitigate confounding variables, with patients being matched in a 1:1 ratio based on propensity scores. The primary outcome was the comparison of postoperative morphine consumption at 24, 48, and 72 hours between the two groups. Secondary outcomes included pain scores, postoperative outcomes, and epidural-related adverse effects. Results A total of 612 patients were included, and after matching, there were 204 patients in each group. Opioid consumption at 24, 48, and 72 hours postoperatively was statistically lower in the epidural analgesia group compared to the intravenous analgesia group (p
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