| Autor: |
Jianbo Lai, Jiajun Jiang, Peifen Zhang, Caixi Xi, Lingling Wu, Xingle Gao, Danhua Zhang, Yanli Du, Qunxiao Li, Xiangyuan Diao, Shaojia Lu, Zheng Wang, Xueqin Song, Shaohua Hu |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Clinical and Translational Medicine, Vol 10, Iss 4, Pp n/a-n/a (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2001-1326 |
| DOI: |
10.1002/ctm2.146 |
| Popis: |
Abstract Trillions of microorganisms inhabiting in the human gut play an essential role in maintaining physical and mental health. The connections between gut microbiome and neuropsychiatric diseases have been recently identified. The pathogenesis of bipolar disorder, a spectrum of diseases manifesting with mood and energy fluctuations, also seems to be involved in the bidirectional modulation of the microbiome‐gut‐brain (MGB) axis. In this review, we briefly introduce the concept of MGB axis, and then focus on the previous findings in human studies associated with bipolar disorder. These studies provided preliminary evidences on the gut microbial alterations in bipolar disorder. Limitations in these studies and future directions in this research field, such as fecal microbiome transplantation and microbiome‐targeted therapy, were discussed. A research framework linking gut microbiome to determinants and health‐related outcomes in BD was also proposed. Better characterizing and understanding of gut microbial biosignatures in bipolar patients contribute to clarify the etiology of this intractable disease and pave the new way for treatment innovation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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