Serum cartilage oligomeric matrix protein is decreased in patients with pulmonary hypertension: a potential protective factor

Autor: Dan‐dan Chen, Wei‐ping Hu, Liang Xie, Gui‐ling Xiang, Qin‐han Wu, Jie‐ming Qu, Shan‐qun Li, Li‐hua Guan, Dong Liu
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Pulmonary Circulation, Vol 11, Iss 4, Pp 1-6 (2021)
Druh dokumentu: article
ISSN: 2045-8940
20458940
DOI: 10.1177/20458940211031111
Popis: Cartilage oligomeric matrix protein (COMP) was a protective factor in the cardiovascular system. Previous studies showed that hypoxia led to decreased COMP in rat models of pulmonary hypertension. However, the expression pattern of COMP in the pulmonary hypertension population was unclear. A total of 35 patients newly diagnosed with pulmonary hypertension and 70 controls were enrolled in the study. Circulating COMP concentrations of serum samples were measured by enzyme‐linked immunosorbent assay and were analyzed the association with multiple clinical variables. Serum COMP concentrations in the pulmonary hypertension group were significantly declined in comparison with age‐ and sex‐matched normal controls, especially in the female subgroup. No significant difference of COMP concentrations was observed in the etiological classification, heart function classification, and risk stratification. Major hemodynamic parameters, six‐minute walk distance, N‐terminal pro brain natriuretic peptide, and short‐term prognosis were not statistically associated with COMP. However, some echocardiography parameters, like tricuspid annular plane systolic excursion and mean right atrial pressure, were found the negative relation to COMP concentrations. In conclusion, serum COMP levels were decreased in the patients with pulmonary hypertension, which was in accordance with its known biological effects. Its association with long‐term prognosis was worth further exploring.
Databáze: Directory of Open Access Journals
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