| Autor: |
Richard Omore, Sammy Khagayi, Billy Ogwel, Reuben Onkoba, John B. Ochieng, Jane Juma, Stephen Munga, Collins Tabu, Sergon Kibet, J. Pekka Nuorti, Frank Odhiambo, Jason M. Mwenda, Robert F. Breiman, Umesh D. Parashar, Jacqueline E. Tate |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Infectious Diseases, Vol 19, Iss 1, Pp 1-11 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2334 |
| DOI: |
10.1186/s12879-018-3615-6 |
| Popis: |
Abstract Background Rotavirus vaccine was introduced in Kenya immunization program in July 2014. Pre-vaccine disease burden estimates are important for assessing vaccine impact. Methods Children with acute gastroenteritis (AGE) (≥3 loose stools and/or ≥ 1 episode of unexplained vomiting followed by loose stool within a 24-h period), hospitalized in Siaya County Referral Hospital (SCRH) from January 2010 through December 2013 were enrolled. Stool specimens were tested for rotavirus (RV) using an enzyme immunoassay (EIA). Hospitalization rates were calculated using person-years of observation (PYO) from the Health Demographic Surveillance System (HDSS) as a denominator, while adjusting for healthcare utilization at household level and proportion of stool specimen collected from patients who met the case definition at the surveillance hospital. Mortality rates were calculated using PYO as the denominator and number of deaths estimated using total deaths in the HDSS, proportion of deaths attributed to diarrhoea by verbal autopsy (VA) and percent positive for rotavirus AGE (RVAGE) hospitalizations. Results Of 7760 all-cause hospitalizations among children |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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