IgG1 as a potential biomarker of post-chemotherapeutic relapse in visceral leishmaniasis, and adaptation to a rapid diagnostic test.
| Autor: | Tapan Bhattacharyya, Armon Ayandeh, Andrew K Falconar, Shyam Sundar, Sayda El-Safi, Marissa A Gripenberg, Duncan E Bowes, Caroline Thunissen, Om Prakash Singh, Rajiv Kumar, Osman Ahmed, Osama Eisa, Alfarazdeg Saad, Sara Silva Pereira, Marleen Boelaert, Pascal Mertens, Michael A Miles |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | PLoS Neglected Tropical Diseases, Vol 8, Iss 10, p e3273 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1935-2727 1935-2735 |
| DOI: | 10.1371/journal.pntd.0003273 |
| Popis: | BACKGROUND: Visceral leishmaniasis (VL), caused by protozoa of the Leishmania donovani complex, is a widespread parasitic disease of great public health importance; without effective chemotherapy symptomatic VL is usually fatal. Distinction of asymptomatic carriage from progressive disease and the prediction of relapse following treatment are hampered by the lack of prognostic biomarkers for use at point of care. METHODOLOGY/PRINCIPAL FINDINGS: All IgG subclass and IgG isotype antibody levels were determined using unpaired serum samples from Indian and Sudanese patients with differing clinical status of VL, which included pre-treatment active VL, post-treatment cured, post-treatment relapsed, and post kala-azar dermal leishmaniasis (PKDL), as well as seropositive (DAT and/or rK39) endemic healthy controls (EHCs) and seronegative EHCs. L. donovani antigen-specific IgG1 levels were significantly elevated in relapsed versus cured VL patients (p |
| Databáze: | Directory of Open Access Journals |
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