EXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSIS
| Autor: | A. E. Petrenko, Y. Sh. Shvartz, S. N. Belogorodtsev |
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| Jazyk: | ruština |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Туберкулез и болезни лёгких, Vol 97, Iss 1, Pp 41-51 (2019) |
| Druh dokumentu: | article |
| ISSN: | 2075-1230 2542-1506 |
| DOI: | 10.21292/2075-1230-2019-97-1-41-51 |
| Popis: | The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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