The analysis of gut microbiota in patients with bile acid diarrhoea treated with colesevelam
| Autor: | Aditi Kumar, Mohammed Nabil Quraishi, Hafid O. Al-Hassi, Mohammed E. El-Asrag, Jonathan P. Segal, Manushri Jain, Helen Steed, Jeffrey Butterworth, Adam Farmer, John Mclaughlin, Andrew Beggs, Matthew J. Brookes |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Frontiers in Microbiology, Vol 14 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1664-302X 40927458 |
| DOI: | 10.3389/fmicb.2023.1134105 |
| Popis: | IntroductionBile acid diarrhoea (BAD) is a common disorder that results from an increased loss of primary bile acids and can result in a change in microbiome. The aims of this study were to characterise the microbiome in different cohorts of patients with BAD and to determine if treatment with a bile acid sequestrant, colesevelam, can alter the microbiome and improve microbial diversity.Materials and methodsPatients with symptoms of diarrhoea underwent 75-selenium homocholic acid (75SeHCAT) testing and were categorised into four cohorts: idiopathic BAD, post-cholecystectomy BAD, post-operative Crohn’s disease BAD and 75SeHCAT negative control group. Patients with a positive 75SeHCAT ( |
| Databáze: | Directory of Open Access Journals |
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