Macrophages in Nonalcoholic Steatohepatitis: Friend or Foe?

Autor: Joel Grunhut, Wei Wang, Berk Aykut, Inderdeep Gakhal, Alejandro Torres-Hernandez, George Miller
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: European Medical Journal Hepatology, Vol 6, Iss 1, Pp 100-109 (2018)
Druh dokumentu: article
ISSN: 2053-4221
Popis: Nonalcoholic steatohepatitis (NASH) is a subtype of nonalcoholic fatty liver disease that is characterised by steatosis, chronic inflammation, and hepatocellular injury with or without fibrosis. The role and activation of macrophages in the pathogenesis of NASH is complex and is being studied for possible therapeutic options to help the millions of people diagnosed with the disease. The purpose of this review is to discuss the pathogenesis of NASH through the activation and role of Kupffer cells and other macrophages in causing inflammation and progression of NASH. Furthermore, this review aims to outline some of the current therapeutic options targeting the pathogenesis of NASH.
Databáze: Directory of Open Access Journals