Search for poliovirus carriers among people with primary immune deficiency diseases in the United States, Mexico, Brazil, and the United Kingdom
| Autor: | Halsey Neal A., Pinto Jorge, Espinosa-Rosales Francisco, Faure-Fontenla María A., Silva Edson da, Khan Aamir J., Webster A.D.B., Minor Philip, Dunn Glynis, Asturias Edwin, Hussain Hamidah, Pallansch Mark A., Kew Olen M., Winkelstein Jerry, Sutter Roland |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Poliovirus/isolation and purification
Carrier state Poliomyelitis/chemically induced Poliomyelitis/transmission Poliovirus vaccine Oral/adverse effects IgA deficiency IgG deficiency Common variable immunodeficiency Agammaglobulinemia United States Mexico Brazil United Kingdom Public aspects of medicine RA1-1270 |
| Zdroj: | Bulletin of the World Health Organization, Vol 82, Iss 1, Pp 3-8 (2004) |
| Druh dokumentu: | article |
| ISSN: | 0042-9686 |
| Popis: | OBJECTIVE: To estimate the rate of long-term poliovirus excretors in people known to have B-cell immune deficiency disorders. METHODS: An active search for chronic excretors was conducted among 306 persons known to have immunoglobulin G (IgG) deficiency in the United States, Mexico, Brazil, and the United Kingdom, and 40 people with IgA deficiency in the United States. Written informed consent or assent was obtained from the participants or their legal guardians, and the studies were formally approved. Stool samples were collected from participants and cultured for polioviruses. Calculation of the confidence interval for the proportion of participants with persistent poliovirus excretion was based on the binomial distribution. FINDINGS: No individuals with long-term excretion of polioviruses were identified. Most participants had received oral poliovirus vaccine (OPV) and almost all had been exposed to household contacts who had received OPV. Polioviruses of recent vaccine origin were transiently found in four individuals in Mexico and Brazil, where OPV is recommended for all children. CONCLUSION: Although chronic poliovirus excretion can occur in immunodeficient persons, it appears to be rare. |
| Databáze: | Directory of Open Access Journals |
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