Effect of Continuous Positive Airway Pressure on Airway Inflammation and Oxidative Stress in Patients with Obstructive Sleep Apnea

Autor: Promsrisuk Tichanon, Khrisanapant Wilaiwan, Santamit Sopida, Pasurivong Orapin, Boonsawat Watchara, Intarapoka Banjamas
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Canadian Respiratory Journal, Vol 2016 (2016)
Druh dokumentu: article
ISSN: 1198-2241
1916-7245
DOI: 10.1155/2016/3107324
Popis: Background. Airway inflammation and oxidative stress may be linked in obstructive sleep apnea (OSA) patients. We determined the effectiveness of continuous positive airway pressure (CPAP) therapy in reducing fractional exhaled nitric oxide (FeNO) and malondialdehyde (MDA) levels in OSA patients. Methods. Thirteen patients with OSA and 13 normal controls were recruited. FeNO and MDA levels were measured in the controls and in OSA patients before and after three months of CPAP therapy. Results. FeNO and MDA levels were higher in the patients compared to the age and gender matched controls (FeNO: 25.9 ± 5.0 versus 17.5 ± 5.9 ppb, P
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