Metabolism Dysregulation in Retinal Diseases and Related Therapies

Autor:	Yingying Chen, Nathan J. Coorey, Meixia Zhang, Shaoxue Zeng, Michele C. Madigan, Xinyuan Zhang, Mark C. Gillies, Ling Zhu, Ting Zhang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	retina metabolism retinal diseases gene therapy lipid metabolism Therapeutics. Pharmacology RM1-950
Zdroj:	Antioxidants, Vol 11, Iss 5, p 942 (2022)
Druh dokumentu:	article
ISSN:	11050942 2076-3921
DOI:	10.3390/antiox11050942
Popis:	The human retina, which is part of the central nervous system, has exceptionally high energy demands that requires an efficient metabolism of glucose, lipids, and amino acids. Dysregulation of retinal metabolism disrupts local energy supply and redox balance, contributing to the pathogenesis of diverse retinal diseases, including age-related macular degeneration, diabetic retinopathy, inherited retinal degenerations, and Macular Telangiectasia. A better understanding of the contribution of dysregulated metabolism to retinal diseases may provide better therapeutic targets than we currently have.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a4757895ac1243f7a25b0566e7659e21 Zobrazit plný text záznamu View record in DOAJ